Elective Single Embryo Transfer (e-SET)

Considering the steps taken to reduce the incidence of multiple pregnancies associated with assisted reproductive therapy (ART), the United States lags behind parts of the world such as Europe and Australia. In the United States, there is widespread evidence that the Electromagnetic Embryo Transfer (e-SET) does not have the same chance of multiple embryo transfer cycles in terms of live birth. The literature from countries that provide substantial funding for the treatment of ART is challenging to this widespread belief.


Should we be involved in trials to reduce the incidence of multiple pregnancies? The short answer is absolutely “Yes”. An overwhelming number of studies in the United States document the risk and burden that multiple pregnancies give to developing babies, women with multiple pregnancies, and families with more than one newborn. In the past, we have intensified our efforts to reduce high-level multiple pregnancies, namely triplets and quadruplets. However, the results of twin pregnancies are also an important burden in the US today.


Certain patient characteristics make patients more vulnerable to the risk of developing twin or high-level multiple pregnancies. These features include one or more female partners under the age of thirty-five, one or more high-quality blastocysts, five embryos, the use of donor eggs, and the number of normal chromosomes regardless of the age of the female partner. The presence of high quality blastocyst.


At our center, obstetricians have the highest percentage of e-SET treatment cycles in Southern California and are truly one of the leaders in the country as a whole. The implementation of e-SET not only reduced the incidence of multiple pregnancies in patients at the highest risk, but also resulted in incredible pregnancy (82%) and live birth (79%) rates. The data obtained from this ongoing study was delivered orally in the annual meeting of the Pacific Rim Reproductive Society in April 2008 and in the annual meeting of the College of Reproductive Biology in May 2008 by the PhD degree Doctor Christine Briton-Jones (former Embryology Embryology Laboratory Specialist).